Selection of Multiresistant Hepatitis B Virus during Sequential Nucleoside‐Analogue Therapy

Mathematical Models of Hepatitis B Virus Dynamics during Antiviral Therapy

Evolution of hepatitis B virus during long-term therapy in patients with chronic hepatitis B.

BACKGROUND Long-term lamivudine (LAM), adefovir (ADV) and entecavir (ETV) treatment induce the emergence of drug-resistant hepatitis B virus (HBV) in patients with chronic hepatitis B infection. AIM To evaluate the LAM, ADV and ETV resistance mutations detected in our patient group. MATERIALS AND METHODS Twenty patients who had received at least two years of treatment with nucleoside/tide a...

Understanding the Complex Patterns Observed during Hepatitis B Virus Therapy

Data from human clinical trials have shown that the hepatitis B virus (HBV) follows complex profiles, such as bi-phasic, tri-phasic, stepwise decay and rebound. We utilized a deterministic model of HBV kinetics following antiviral therapy to uncover the mechanistic interactions behind HBV dynamics. Analytical investigation of the model was used to separate the parameter space describing virus d...

The Absence of Hepatitis C Virus Infection Among Patients with Hepatitis B virus in Mashhad, Iran

Background and Aims: Many studies have provided evidence for the role of hepatitis B and C viruses in the development of liver cancer. Although the routine treatment is available for both conditions, no definite guideline is available to treat patients dually infected with HBV and HCV. This study was performed to determine the frequency of HBV/HCV-coinfection in Mashhad, North-East of Iran. Mat...

Evolution of hepatitis B virus during long-term therapy in patients with chronic hepatitis

Background. Long-term lamivudine (LAM), adefovir (ADV) and entecavir (ETV) treatment induce the emergence of drug-resistant hepatitis B virus (HBV) in patients with chronic hepatitis B infection. Aim. To evaluate the LAM, ADV and ETV resistance mutations detected in our patient group. Materials and methods. Twenty patients who had received at least two years of treatment with nucleoside/tide an...